Dopamine blockade reduces analysis and drug use behaviors
Blocking dopamine receptors in several areas of the amygdala reduces drug-taking conduct with variable longevity, in response to a rat research revealed in eNeuro.
The amygdala comprises receptors for dopamine, a neurotransmitter concerned within the seek for rewards. It has been proven to affect cocaine reward behaviors, making it a goal for drug therapy analysis.
Matthew Lattal and Earnest Kim of Oregon Well being & Science College blocked dopamine receptors within the amygdala of rats self-administering cocaine. The rats had been skilled to press a lever that confirmed one other lever, which modeled the drug-seeking conduct, and to press the second lever to obtain a dose of cocaine, which was drug-taking conduct.
Blockade of dopamine receptors within the basolateral tonsil progressively decreased drug-seeking and drug-taking behaviors, even when rats had been positioned in a brand new atmosphere. Within the central amygdala, the blockage of dopamine has brought on a fast lower within the variety of functions and drug consumption. The impact is reversed when the rats entered a brand new atmosphere.
These findings make clear the distinctive roles of the basolateral and central amygdala and reveal that blocking dopamine throughout cocaine use weakens the consequences of the drug. This provides perception into potential therapies for habit and relapse.
Kim, E. et al. (2019) Context-dependent and unbiased results of D1 receptor antagonism in basolateral and central tonsils throughout cocaine self-administration. in Euro. doi.org/10.1523/ENEURO.0203-19.2019.